Meta-analysis: patients with atopic dermatitis have increased asthma risk

  • Ravnborg N & al.
  • J Am Acad Dermatol
  • 26 Feb 2020

  • curated by Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • Patients with atopic dermatitis have a higher prevalence of asthma compared with those without the condition, according to a systematic review and meta-analysis.

Why this matters

  • These results suggest a need for heightened awareness of asthma symptoms in patients with atopic dermatitis.

Key results

  • Pooled prevalence of asthma was higher in patients with vs without atopic dermatitis:
    • 25.7% (95% CI, 23.7%-27.7%) vs
    • 8.1% (95% CI, 7.0%-9.4%).
  • The association between atopic dermatitis and asthma was statistically significant (ORs; 95% CIs):
    • 3.03 (2.64-3.47), overall.
    • 3.01 (2.41-3.77) with physician-diagnosed atopic dermatitis and asthma.
    • 2.46 (2.08-2.90) with asthma defined as wheeze.

Study design

  • Meta-analysis of 213 studies that included 688,927 patients with atopic dermatitis and 2,223,921 without it.
  • Funding: None.

Limitations

  • Heterogeneity among included studies.