Meta-analysis: psoriasis linked to all-cause mortality

  • J Am Acad Dermatol

  • curated by Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • A systematic review and meta-analysis suggest that psoriasis is associated with all-cause mortality, with higher disease severity predicting increased risk.

Why this matters

  • Meta-analysis provides additional support for a link between psoriasis and mortality risk, likely as the result of a high comorbidity rate.

Key results

  • Psoriasis was associated with risk for all-cause mortality (risk ratio [RR], 1.21; 95% CI, 1.14-1.28; 6 studies; 299,374 patients).
    • RR, 1.13 (95% CI, 1.09-1.16) for mild psoriasis (4 studies; 265,292 patients).
    • RR, 1.52 (95% CI, 1.35-1.72) for severe psoriasis (6 studies; 36,428 patients).
  • Psoriasis was associated with risk for cardiovascular mortality (RR, 1.15; 95% CI, 1.09-1.21; 5 studies; 285,675 patients).
    • RR, 1.05 (95% CI, 0.92-1.20) for mild psoriasis (3 studies; 188,223 patients).
    • RR, 1.38 (95% CI, 1.09-1.74) for severe psoriasis (4 studies; 17,317 patients).
  • Psoriasis was also associated with risk for mortality from kidney disease (RR, 2.16; 95% CI, 1.37-3.40), liver disease (RR, 2.00; 95% CI, 1.34-2.99), and infections (RR, 1.24; 95% CI, 1.14-1.31).

Study design

  • 12 studies were subjected to meta-analysis.
  • Funding: None.

Limitations

  • Heterogeneity between studies.

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