- Pretreatment with testosterone may improve the success of in vitro fertilization (IVF) in patients with poor ovarian response (POR).
Why this matters
- POR is a major challenge for fertility care providers, especially in older patients, who are at considerably greater risk for IVF failure.
- Researchers analyzed 7 randomized controlled trials evaluating the effects of testosterone supplementation on IVF outcomes in patients with POR (N=573).
- Primary outcome: live birth rate (LBR).
- Secondary outcomes: clinical pregnancy rate (CPR), miscarriage rate, total and meiosis II (MII) oocytes, total embryos.
- Funding: None.
- Women receiving testosterone showed higher (95% CIs):
- LBR: risk ratio (RR), 2.29 (1.31-4.01; P=.004).
- CPR: RR, 2.32 (1.47-3.64; P=.0003).
- Total oocytes: mean difference (MD), 1.28 (0.83-1.73; P<.00001>
- MII oocytes: MD, 0.96 (0.28-1.65; P=.006).
- Total embryos: MD, 1.17 (0.67-1.67; P<.00001>
- They showed no difference in miscarriage rate (P value not significant).
- Researchers calculated outcomes by pooling the results of a small number of studies, patients, and events.
- Findings should be confirmed by a large trial with rigorous methodology and inclusion criteria.