- Metabolic syndrome (MetS) is associated with longer time to pregnancy (TTP) and infertility, independent of obesity.
Why this matters
- Modifications to metabolic profile may reduce the risk of pregnancy complications and cardiovascular disease in later life.
- This Screening for Pregnancy Endpoints (SCOPE) study enrolled 5519 nulliparous pregnant women with singleton pregnancies.
- Data on retrospectively reported TTP and a blood sample to assess metabolic health were collected between 14-16 weeks of gestation.
- Funding: National Health Service.
- Of 5519 pregnant women, 684 (12.4%) reported MetS.
- After adjustment for confounders, women with MetS vs those without had a longer TTP (adjusted time ratio, 1.30; 95% CI, 1.15-1.46) which was similar in obese and non-obese women.
- Marginal estimates for median TTP was 3.1 (3.0-3.3) months in women with MetS vs 4.1 (3.6-4.5) months in those without MetS.
- Women with MetS were at a greater risk for infertility (adjusted relative risk [aRR], 1.62; 95% CI, 1.32-1.99) and were at a greater risk for infertility whether they were obese (aRR, 1.62; 95% CI, 1.15-2.29) or not (aRR, 1.73; 95% CI, 1.33-2.23).
- Reduced high-density lipoprotein cholesterol and elevated triglycerides were the main components associated with risk for infertility.
- MetS was assessed at 14-16 weeks of gestation rather than pre-pregnancy.