Metabolic syndrome tied to risk for thyroid nodules

  • Guo W & al.
  • Endocrine
  • 27 Mar 2019

  • International Clinical Digest
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Takeaway

  • A cross-sectional study suggests that patients with metabolic syndrome (MetS) are at increased risk of thyroid nodules and enlarged thyroid volume.

Why this matters

  • The relationship between MetS and thyroid nodules/volume is controversial, especially when considering age and sex.

Key results

  • 26.13% of subjects had thyroid nodules and 29.43% had MetS.
  • MetS was associated with increased risk of thyroid nodules in analysis adjusted for age, sex, education, income, smoking status, and salt intake (OR, 1.23; P=.0429).
    • Increased thyroid nodule risk was significant in men (OR, 1.38; P=.0228), but not in women (OR, 1.02; P=.8886), although the interaction effect of sex and MetS on thyroid nodules was not statistically significant (P=.94).
    • Increased thyroid nodules risk was significant in subjects aged
  • MetS and thyroid nodules were both correlated with greater thyroid volume (P=.0037 and P<.0001 respectively>

Study design

  • 2606 subjects were included and analyzed for associations between MetS, thyroid nodules, and thyroid volume.
  • Funding: National Natural Science Foundation of China, Tianjin Education Committee Social Science Major Project, Tianjin Science and Technology Committee Project Foundation.

Limitations

  • Cross-sectional study design.

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