Metastatic melanoma: which BRAF/MEK inhibitor combination is best?

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Takeaway
  • Indirect comparison of dabrafenib (Tafinlar) plus trametinib (Mekinist) with vemurafenib (Zelboraf) plus cobimetinib (Cotellic) suggests the 2 combinations have similar efficacy in metastatic melanoma, but adverse events are lower with dabrafenib plus trametinib.
Why this matters
  • These fi...