- In patients with metastasized pancreatic ductal adenocarcinoma (PDAC), tail origin of the tumor was associated with a unique metastatic profile and shortened survival.
Why this matters
- Previous studies have not examined the relationship among primary tumor location, metastatic patterns, and survival.
- Some small, nonrandomized studies have indicated that local ablative therapy or surgery may be sufficient for patients with favorable outcomes.
- Retrospective analysis of adults diagnosed with PDAC or suspected PDAC in the Netherlands between 2005 and 2015 (n=9952).
- Funding: Dutch Cancer Society.
- Location of primary tumor: 57% head, 17% body, 26% tail.
- Percentage of tumors >4 cm in size by primary tumor location: head, 26%; body, 41%; tail, 52% (P<.0001>
- Percentage with ≥3 metastases: tail, 15%; body, 9%; head, 5% (P<.0001>
- Percentage of cases with peritoneal metastases: tail, 30%; body, 24%; head, 13% (P<.0001 tail origin tumors also had higher proportions of liver lung and other metastases although these differences were less pronounced.>
- Median OS: tail, 1.9 months (HR compared with head, 1.20; 95% CI, 1.15-1.26); body, 2.4 months; head, 2.6 months.
- Retrospective analysis.