- Among Diabetes Prevention Program (DPP) participants with ≥5% weight loss after 1 year, those originally randomly assigned to metformin had the greatest weight loss in years 6-15.
- Older age and amount of initial weight loss predicted long-term weight loss (LTWL) maintenance.
Why this matters
- Weight loss is a key to preventing or delaying type 2 diabetes (T2D).
- The DPP was a randomized controlled trial of 3234 participants with prediabetes mellitus (pre-DM), comparing weight loss with metformin, intensive lifestyle intervention (ILS), or placebo.
- Participants are followed observationally in the DPP Outcomes Study.
- Funding: NIH.
- Number of participants with ≥5% weight loss in year 1:
- 289 (28.5%) in metformin group,
- 640 (62.6%) ILS, and
- 137 (13.4%) placebo.
- Mean weight losses from baseline across years 6-15:
- 6.2% (95% CI, 5.2%-7.2%) in metformin group,
- 3.7% (3.1%-4.4%) ILS, and
- 2.8% (1.3%-4.4%) placebo.
- Mean percentages with LTWL for years 6-15 were:
- 56.1% (55.1%-57.1%) for metformin,
- 43.1% (42.1%-44.1%) ILS, and
- 41.9% (39.9%-43.9%) placebo, respectively.
- Independent predictors of LTWL included greater first-year weight loss in all groups and older age and continued metformin use in the metformin group.
- Post-hoc analysis.
- Examination of nonrandomized subsets after year 1.