- Midlife insomnia and late-life terminal insomnia or long sleep duration earlier in late life were associated with late-life dementia risk.
- Different stages in the life course are sensitive to specific sleep disturbances and insomnia, which in turn raise the risk for dementia.
Why this matters
- Findings suggest that people with sleep disturbances warrant closer clinical attention and may benefit from lifestyle changes and interventions that aid in improving sleep quality, such as cognitive behavioral therapy.
- Systematic review of 3 studies including 1446 patients (Cardiovascular Risk Factors, Aging, and Dementia [CAIDE] study, n=703; H70 study, n=437; and Kungsholmen Project, n=306) with sleep disturbance.
- Funding: None disclosed.
- Dementia risk was higher in patients with midlife insomnia (aHR, 1.24; 95% CI, 1.02-1.50) and late-life terminal insomnia (aOR, 1.94, 95% CI, 1.08-3.49).
- Long sleep duration during late life (>9 hours) was associated with increased risk for dementia (aOR, 3.98; 95% CI, 1.87-8.48) vs patients with 7 to 8 hours sleep duration.
- The incidence of initial insomnia in late life (aOR, 0.53; 95% CI, 0.15-1.90) and short sleep duration (2-6 hours/night; aOR, 0.74; 95% CI, 0.36-1.53) in late life showed no association with increased risk for dementia.
- Self-reported sleep measures.
- Daytime sleepiness was not assessed.