- Women with migraine and their offspring are at elevated risk for a variety of adverse pregnancy outcomes.
Why this matters
- Up to one-quarter of reproductive-age women have migraine.
- Women with migraine had increased risks:
- Pregnancy-associated hypertension disorders (adjusted prevalence ratio, 1.50; 95% CI, 1.39-1.61).
- Miscarriage (1.10; 1.05-1.15).
- Low birth weight (1.14; 1.06-1.23).
- Preterm birth (1.21; 1.13-1.30).
- Cesarean delivery (1.20; 1.15-1.25).
- But no significant increases in risks for small for gestational age offspring, birth defects.
- Offspring of women with migraine had increased neonatal, postnatal risks:
- Neonatal intensive care unit (NICU) admission (adjusted risk ratio, 1.22; 95% CI, 1.03-1.45).
- Hospitalization (1.12; 1.06-1.18).
- Dispensed prescriptions (1.34; 1.24-1.45).
- Respiratory distress syndrome (1.20; 1.02-1.42).
- Febrile seizures (1.27; 1.03-1.57).
- But no significant increases in risks for death, epilepsy, cerebral palsy.
- Findings similar in subset of pregnancies among women receiving migraine treatment only during second or third trimester.
- Danish population-based cohort study 2005-2012 of 22,841 pregnancies among nonepileptic women with migraine and 228,324 age- and conception year-matched pregnancies among nonepileptic women without migraine.
- Main outcomes: pregnancy, birth, neonatal, and postnatal outcomes.
- Funding: Amgen Inc.
- Possible misclassification of migraine status.
- Potential unmeasured confounding.