Migraine tied to increased risk for ischaemic stroke

  • Lee SY & al.
  • BMJ Open
  • 2 Apr 2019

  • curated by Sarfaroj Khan
  • UK Clinical Digest
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • Migraine was associated with increased risk for ischaemic stroke but not haemorrhagic stroke.
  • Young women with migraine were at increased risk of developing ischaemic stroke.

Why this matters

  • Although accumulating evidence has supported the association between migraine and stroke, its causal association remains unknown.

Study design

  • Longitudinal follow-up study of patients with migraine (n=41,585) and 1:4 matched control participants (n=166,340) using data from a national cohort between 2002 and 2013.
  • Funding: Hallym University Research and National Research Foundation of Korea.

Key results

  • Risk for ischaemic stroke was higher in migraine group vs control group (2.3% vs 2.0%; aHR, 1.18; P<.001 but no significant difference in risk for haemorrhagic stroke between groups>
  • In subgroup analysis, risk for ischaemic stroke was higher in young women (age, 20-39 years; aHR, 2.31; P=.001) followed by middle-aged (aged 40-59 years; aHR, 1.32; P=.006) and old women (age, ≥60 years; aHR, 1.18; P=.002).
  • Patients who reported migraine with aura and migraine without aura had increased risk for ischaemic stroke vs control group (aHR, 1.44; P=.009) and (aHR, 1.15; P<.001 respectively but no increased risk of haemorrhagic stroke>
  • Risk for haemorrhagic stroke in any age group did not significantly differ between 2 groups.

Limitations

  • Data on stroke subtypes and location were not included.
  • Study did not consider risk factors for stroke such as cigarette smoking, obesity and migraine-specific drugs.

Please confirm your acceptance

To gain full access to GPnotebook please confirm:

By submitting here you confirm that you have accepted Terms of Use and Privacy Policy of GPnotebook.

Submit