- Migraine with aura is linked to increased carotid thickening in middle-aged women.
- Migraine without aura shows reduced risk associated with carotid plaque or arterial stiffening vs women without migraine.
- Consider carotid ultrasound in women with migraine.
Why this matters
- These findings add to growing evidence that migraine with aura specifically involves increased risk for cardiovascular disease, including stroke and
- Compared with women with no migraines, those who had migraine and aura had increased risk for diffuse carotid thickening: 3/46 (6.5%) vs 2/165 (1.2%); adjusted OR, 7.12; 95% CI, 1.05-48.49.
- Compared with women with no migraines, those who had migraine and no aura had:
- reduced carotid plaque risk: aOR, 0.28 (95% CI, 0.08-0.99); and
- reduced arterial stiffening risk: aOR, 0.39 (95% CI, 0.19-0.79).
- No associations found for duration, frequency, pain intensity.
- Cross-sectional study, 277 (112 with migraine, 46 of them with aura) middle-aged women (median age, 57 [interquartile range, 52-61] years) without known cardiovascular disease.
- Outcome: migraine feature association with carotid thickening, carotid plaques, arterial stiffening
- Funding: None.
- Involved only middle-aged women.
- Potential treatment confounding.