Moderate-severe psoriasis: complete clearance seen in only 1 in 4 treated with biologics

  • Seneschal J & al.
  • J Eur Acad Dermatol Venereol
  • 4 May 2020

  • curated by Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • Among patients with moderate to severe plaque psoriasis, 22.7% achieved complete skin clearance after 6 months of biologic treatment, according to a real-world study (PSO-BIO-REAL).

Why this matters

  • These results suggest an unmet need for more effective psoriasis treatment.

Key results

  • At 6 months, 22.7% of patients had achieved complete skin clearance.
  • At 12 months, 26.1% of patients had achieved complete skin clearance.
  • Biologic-treated patients had lower rates of complete skin clearance compared with biologic-naive patients:
    • At 6 months: 19.6% vs 24.9%. 
    • At 12 months: 19.5% vs 30.4%.

Study design

  • 846 patients from 5 countries were included, all with moderate to severe plaque psoriasis.
  • 40% of patients were biologic-experienced and 60% of patients were biologic-naive.
  • Funding: Amgen/AstraZeneca; LEO Pharma.

Limitations

  • Observational.