- Varicose veins are linked to increased mortality and cardiovascular (CV) event risk, especially in men.
Why this matters
- These authors say that their findings warrant close attention to prognosis and treatment in patients with varicose veins.
- Most patients with varicose veins did not have systemic disease but did have worse outcomes vs those without varicose veins.
- Adjusted HR for all-cause mortality was higher with varicose veins:
- 1.37 (95% CI, 1.19-1.57).
- Older age and being male intensified this risk (adjusted HRs; 95% CIs):
- Age ≥65 years: 1.38 (1.17-1.62).
- Male: 1.41 (1.18-1.68).
- HR for major cardiac events also increased with varicose veins vs without:
- 2.05 (95% CI, 1.89-2.23).
- In this case, younger age intensified the risk (adjusted HRs; 95% CIs), along with being male:
- Male: 2.32 (2.06-2.62).
- Severe varicose veins were also linked to increased thrombotic event risk:
- Adjusted HR, 38.4 (95% CI, 16.4-90.1).
- Taiwan national insurance database data for 4644 patients with a new varicose vein diagnosis, 1999-2012, propensity score-matched by age, chronic CV risk factors, and sex to 3 groups of controls for comparison by 3 severity grades.
- Funding: Chi-Mei Medical Center.
- Not all varicose vein-related risk factors, such as smoking, overweight, were available.