- Patients surviving Staphylococcus aureus infections have almost 25% odds of readmission.
- Methicillin-resistant S aureus (MRSA) bacteremia is associated with recurrent bacteremia (especially in concurrent endocarditis), hospital readmission, increased length of stay (LOS), and in-hospital mortality.
Why this matters
- Monitor patients with endocarditis carefully to reduce treatment failure.
- Optimize management in patients with comorbid, high-risk conditions most associated with readmission.
- 92,089 (standard error [SE] 1905) S aureus bacteremia cases; 48.5% (44,653 cases, SE 1030) had MRSA bacteremia.
- All-cause 30-day readmission among S aureus patients: 22%.
- Patients with MRSA were 17% likelier to have 30-day readmission with S aureus bacteremia recurrence (HR, 1.17; 95% CI, 1.02-1.34) vs those with methicillin-susceptible S aureus (MSSA).
- Coexisting index endocarditis was associated with 30-day readmission (HR, 1.44; 95% CI, 1.21-1.72; P<.001>
- Patients with MRSA bacteremia had 15% greater odds of in-hospital death (OR, 1.15; 95% CI, 1.07-1.23), as well as longer LOS (incidence rate ratio, 1.09; 95% CI, 1.06-1.11) vs MSSA patients.
- Retrospective analysis evaluating population-based estimates of 30-day readmission due to S aureus by methicillin susceptibility, mortality, LOS.
- Funding: No external funding.
- ICD-9-CM coding bias.
- Selection bias.
- Readmission bias.
- Lack of data on link between prostheses and infection.
- Residual confounding.