- In patients with newly diagnosed multiple myeloma (NDMM), the combined use of positron emission tomography-computed tomography (PET-CT) and minimal residual disease (MRD) assessment by multiparameter flow cytometry (MFC) enabled improved predictive power in identifying patient subgroups with different prognoses.
Why this matters
- MM is characterized by relatively homogenous bone marrow infiltration; however, MRD assessment based on bone marrow samples is of limited utility in assessing patients with extramedullary disease or heterogeneous bone marrow involvement.
- Study to investigate the prognostic value of combining PET-CT with MRD assessment by MFC in 103 patients with NDMM.
- PET-CT and MFC assessments were performed before and at successive points during first-line therapy.
- Median patient age: 62 (range, 38-82) years.
- Funding: Instituto de Salud Carlos III.
- Significant differences in median PFS in 87 patients in complete remission (CR) per complementary assessment results (P<.001 style="list-style-type:circle;">
- 92 months in patients who were MRD-negative and PET-negative.
- 57 months in patients who were MRD-positive and PET-negative.
- 31 months in patients who were PET-positive.
- Retrospective data.