- Multiple primary tumors are associated with reduced survival compared with a single primary tumor in patients with cutaneous melanoma.
Why this matters
- Conflicting results have been reported for survival of patients with single vs multiple primary melanomas.
- Patients with multiple primary melanomas had worse OS compared with patients with a single primary melanoma (HR, 1.31; P<.001>
- Median Breslow thickness was significantly lower for the second melanoma compared with for the first melanoma (0.65 vs 0.90 mm; P<.001 style="list-style-type:circle;">
- No significant differences were found between the second and subsequent melanomas.
- 56,929 patients with invasive cutaneous melanoma from the Dutch Nationwide Network and Registry of Histopathology and Cytopathology were included, with follow-up data retrieved from the Netherlands Cancer Registry.
- Funding: None disclosed.
- Retrospective analysis of large database.
- In situ melanoma cases not included.