Multiple primary melanomas tied to poorer survival

  • El Sharouni MA & al.
  • JAMA Dermatol
  • 26 Jun 2019

  • curated by Brian Richardson, PhD
  • Univadis Clinical Summaries
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Takeaway

  • Multiple primary tumors are associated with reduced survival compared with a single primary tumor in patients with cutaneous melanoma.

Why this matters

  • Conflicting results have been reported for survival of patients with single vs multiple primary melanomas.

Key results

  • Patients with multiple primary melanomas had worse OS compared with patients with a single primary melanoma (HR, 1.31; P<.001>
  • Median Breslow thickness was significantly lower for the second melanoma compared with for the first melanoma (0.65 vs 0.90 mm; P<.001 style="list-style-type:circle;">
  • No significant differences were found between the second and subsequent melanomas.
  • 36.8% of second primary melanomas were found during the first year of follow-up, whereas 27.3% were found after 5 years of follow-up.
  • 16.2% of second melanomas had a higher T stage, 48.7% had the same T stage, and 35.1% had a lower T stage (P<.001>

    Study design

    • 56,929 patients with invasive cutaneous melanoma from the Dutch Nationwide Network and Registry of Histopathology and Cytopathology were included, with follow-up data retrieved from the Netherlands Cancer Registry.
    • Funding: None disclosed.

    Limitations

    • Retrospective analysis of large database.
    • In situ melanoma cases not included.
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