Takeaway
- Meta-analysis of observational studies suggests that patients with multiple sclerosis show 29% increased prevalence and 92% higher incidence of psoriasis.
Why this matters
- Findings call for large prospective studies to evaluate association between multiple sclerosis and psoriasis.
- Patients with multiple sclerosis may need careful monitoring.
Study design
- Meta-analysis of 11 studies including 1,112,832 participants were identified after a search on MEDLINE, Embase, and CENTRAL until July 2018.
- Funding: None.
Key results
- Case control and cross-sectional studies:
- 9 studies (5 case control, 4 cross-sectional) including 18,456 patients with multiple sclerosis and 870,149 individuals without multiple sclerosis.
- Presence of multiple sclerosis was associated with a significantly higher prevalence of psoriasis (pooled OR, 1.29; 95% CI, 1.14-1.45).
- Cohort studies:
- 2 studies including 25,187 patients with multiple sclerosis and 227,225 individuals without multiple sclerosis.
- Patients with multiple sclerosis had a significantly increased risk for psoriasis (pooled HR, 1.92; 95% CI, 1.32-2.80).
Limitations
- Heterogeneity between studies.
- Causal relationship cannot be evaluated.
References
References