Nasopharyngeal cancer: postradiation sinusitis predicts recurrence

  • Huang CJ & al.
  • Radiat Oncol
  • 11 Apr 2019

  • curated by Brian Richardson, PhD
  • Univadis Clinical Summaries
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Takeaway

  • Sinusitis after intensity-modulated radiation therapy (IMRT) is associated with recurrence in patients with nonmetastatic nasopharyngeal carcinoma (NPC).

Why this matters

  • Accurate prognostic markers are needed for patients treated with IMRT.

Key results

  • For the entire cohort, 3-year OS, DFS, local failure-free survival (LFFS), and distant failure-free survival (DFFS) rates were 91.4%, 80.3%, 90.6%, and 87.5%, respectively.
  • Sinusitis was associated with reduced OS (84.4% vs 97.4%; P=.008), DFS (66.5% vs 92.1%; P<.001 lffs vs and dffs compared with lack of sinusitis in univariate analysis: style="list-style-type:circle;">
  • HR, 3.734 (P=.001) for DFS in multivariate analysis.
  • HR, 8.944 (P=.004) for LFFS in multivariate analysis.
  • HR, 2.951 (P=.015) for DFFS in multivariate analysis.
  • Sinusitis had 97.5% negative predictive value for local relapse.
  • Study design

    • 230 patients with nonmetastatic NPC who received IMRT were analyzed for outcomes.
    • Funding: Ministry of Health and Welfare, Taiwan, Republic of China; Kaohsiung Medical University Hospital.

    Limitations

    • Retrospective study.

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