Nasopharyngeal cancer: primary tumor ADC predicts local relapse

  • Huang TX & al.
  • BMC Cancer
  • 17 May 2019

  • curated by Brian Richardson, PhD
  • Univadis Clinical Summaries
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Takeaway

  • The pretreatment primary lesion apparent diffusion coefficient (ADC) is associated with local relapse-free survival (LRFS) and DFS in patients with locally advanced nasopharyngeal carcinoma (LA-NPC).

Why this matters

  • Identification of prognostic factors can assist in patient management; the ADC is obtained from diffusion-weighted MRI and has previously demonstrated prognostic value in small studies.

Key results

  • At a cutoff value of 784.5×10−6 mm2/second, the ADC had sensitivity of 0.640, specificity of 0.574, and area under the curve of 0.604 for predicting local relapse.
  • Patients with low ADC (below the cutoff) had improved 3-year LRFS (96.2% vs 91.4%; P=.003) and DFS (81.4%, vs 73.0%; P=.0056) compared with patients with high ADC (at or above the cutoff).
  • ADC was independently associated with LRFS (HR, 2.04; P=.017) and DFS (HR, 1.41; P=.024) in multivariate analysis.

Study design

  • 843 patients with newly diagnosed LA-NPC were included.
  • Funding: None.

Limitations

  • Retrospective study.
  • No standardization of scanning parameters.