Nasopharyngeal carcinoma: extensive tumor invasion predicts poor outcomes in T3-4 disease

  • Xue F & al.
  • Oral Oncol
  • 20 Nov 2019

  • curated by Brian Richardson, PhD
  • Univadis Clinical Summaries
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Takeaway

  • Extensive invasion of the primary gross tumor volume (GTV) is associated with poor local control and failure-free survival (FFS) of patients with T3-4 nasopharyngeal carcinoma (NPC).

Why this matters

  • Prognostic factors can help guide patient management.

Key results

  • GTV-E was defined as the extensive invasion part of the primary GTV (infiltration of bony structures at skull base, cervical vertebra, or paranasal sinuses, or with intracranial extension).
  • GTV-E of 22.35 mL had 66.7% sensitivity and 75.0% specificity for predicting local control (P=.001).
  • Large (≥22 mL) GTV-E was associated with poor LC (HR, 3.805; P=.035) and FFS (HR, 1.960; P=.045) in multivariate analysis.

Study design

  • 159 patients with nonmetastatic T3-4 NPC were analyzed for associations between GTV, control, and survival outcomes.
  • Funding: Shanghai Anticancer Association; Fudan University Shanghai Cancer Center.

Limitations

  • Plasma Epstein-Barr virus DNA load, an independent prognostic factor, was not systematically tested.