- Extensive invasion of the primary gross tumor volume (GTV) is associated with poor local control and failure-free survival (FFS) of patients with T3-4 nasopharyngeal carcinoma (NPC).
Why this matters
- Prognostic factors can help guide patient management.
- GTV-E was defined as the extensive invasion part of the primary GTV (infiltration of bony structures at skull base, cervical vertebra, or paranasal sinuses, or with intracranial extension).
- GTV-E of 22.35 mL had 66.7% sensitivity and 75.0% specificity for predicting local control (P=.001).
- Large (≥22 mL) GTV-E was associated with poor LC (HR, 3.805; P=.035) and FFS (HR, 1.960; P=.045) in multivariate analysis.
- 159 patients with nonmetastatic T3-4 NPC were analyzed for associations between GTV, control, and survival outcomes.
- Funding: Shanghai Anticancer Association; Fudan University Shanghai Cancer Center.
- Plasma Epstein-Barr virus DNA load, an independent prognostic factor, was not systematically tested.