- High expression of programmed cell death ligand-1 (PD-L1) is associated with poor survival outcomes of patients with nasopharyngeal carcinoma (NPC), according to a systematic review and meta-analysis.
Why this matters
- Prognostic biomarkers can help guide patient management.
- High PD-L1 expression was associated with reduced OS (9 studies; HR, 1.48; P=.049).
- In subgroup analysis, PD-L1 expression was associated with OS in patients with stage II-III disease (P=.016), stage III-IV disease (P=.049), and recurrent/previously treated patients (P=.044).
- High PD-L1 expression was not significantly associated with DFS (6 studies; HR, 1.51; P=.162), distant metastasis-free survival (3 studies; HR, 1.75; P=.277), or local recurrence-free survival (2 studies; HR, 0.67; P=.756).
- 11 studies (1315 patients with NPC) were included in the meta-analysis.
- Funding: None disclosed.
- Heterogeneity between included studies.