- A 5-factor comprehensive nutritional index (CNI) is associated with QoL and predicts survival outcomes after intensity-modulated radiation therapy (IMRT) for nasopharyngeal carcinoma (NPC).
Why this matters
- Predicting treatment outcomes can help with patient management.
- IMRT was associated with significant changes in BMI, usual body weight percentage, albumin, hemoglobin, and total lymphocyte count (P<.001 for all>
- Low CNI, based on the above factors, was associated with reduced QoL (P<.05 for all subscales of the european organization research and treatment cancer quality life questionnaire core-30 head neck module poor os>
- CNI was associated with OS in multivariate analysis (HR, 0.544; P=.046).
- Retrospective study of 359 patients undergoing IMRT for NPC.
- Funding: Medical Research Foundation of Guangdong Province; Nurses Fund of Sun Yat-sen University Cancer Center; Nursing Youth Talents Foundation of Sun Yat-sen University.
- Heterogenous patient treatment.
- Effect of psychological problems on CNI was not investigated.