Nasopharynx cancer: new nutritional index prognostic for IMRT outcomes

  • Deng J & al.
  • Oral Oncol
  • 18 Sep 2019

  • curated by Brian Richardson, PhD
  • Univadis Clinical Summaries
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Takeaway

  • A 5-factor comprehensive nutritional index (CNI) is associated with QoL and predicts survival outcomes after intensity-modulated radiation therapy (IMRT) for nasopharyngeal carcinoma (NPC).

Why this matters

  • Predicting treatment outcomes can help with patient management.

Key results

  • IMRT was associated with significant changes in BMI, usual body weight percentage, albumin, hemoglobin, and total lymphocyte count (P<.001 for all>
  • Low CNI, based on the above factors, was associated with reduced QoL (P<.05 for all subscales of the european organization research and treatment cancer quality life questionnaire core-30 head neck module poor os>
  • CNI was associated with OS in multivariate analysis (HR, 0.544; P=.046).

Study design

  • Retrospective study of 359 patients undergoing IMRT for NPC.
  • Funding: Medical Research Foundation of Guangdong Province; Nurses Fund of Sun Yat-sen University Cancer Center; Nursing Youth Talents Foundation of Sun Yat-sen University.

Limitations

  • Heterogenous patient treatment.
  • Effect of psychological problems on CNI was not investigated.