- Older adults with mild cognitive impairment (MCI) were at elevated risk for dementia if they had affective symptoms or psychotic symptoms, but not if they had hyperactivity symptoms.
Why this matters
- Previous research has focused on individual symptoms rather than symptom clusters.
- 3 symptom clusters were identified:
- Affective symptoms: depression, anxiety, apathy, sleep, appetite (54.1% of patients).
- Hyperactivity symptoms: agitation, irritability, disinhibition (34.3% of patients).
- Psychotic symptoms: delusions, hallucinations (4.8% of patients).
- During median 4-year follow-up among 5957 patients, 41.6% developed dementia.
- Dementia risk was significantly elevated among patients with:
- Affective symptoms (HR, 1.6; P<.001>
- Psychotic symptoms (HR, 1.6; P=.004).
- Prospective cohort study of 8530 patients aged ≥60 years (median, 76 years) with MCI seen at Alzheimer’s Disease Centers across the United States.
- All completed Neuropsychiatric Inventory–Questionnaire at baseline.
- Main outcome: dementia.
- Funding: National Institute on Aging.
- Patients were volunteers, mostly white, well-educated.
- Large majority of dementia cases were Alzheimer’s disease.