- Cancer pain treatment should be tailored to patient's needs and the specific cause of the pain.
Why this matters
- Neuropathic pain is highly prevalent in pancreatic, primary bone, lung, and head and neck cancers, and 40% of cancer survivors present with pain.
- Regular, self-reported assessment of pain intensity using a validated multidimensional assessment tool is necessary.
- Nonopioids like paracetamol and NSAIDs have anti-inflammatory, analgesic, and antipyretic properties and are effective for mild or moderate pain.
- For moderate pain, mild opioids like codeine, dihydrocodeine, and tramadol can be used, and can also be given in a combination with a nonopioid analgesic.
- For severe pain, strong opioids like morphine, methadone, oxycodone, hydromorphone, fentanyl, and buprenorphine can be used in titred dose to get maximum benefit and minimal toxicity.
- Opioid rotation can be followed in patients experiencing pain often to avoid toxicity and obtain better analgesia.
- Other treatment methods like interventional therapies, peripheral and autonomic nerve blocks, neuroaxial infusion, vertebroplasty/kyphoplasty, and radiation therapy can be used.
Coauthored with Anand Ramanathan, PharmD