- New-onset Afib (NAF) is associated with a significant increase in mortality risk among patients with advanced chronic kidney disease (CKD).
- Dialysis confers a significant survival benefit and should be considered standard of care in patients with NAF and CKD.
Why this matters
- CKD is associated with an increased prevalence of NAF.
- Nested case-control study of 3673 dialysis patients aged ≥20 years, matched 1:2 with nondialysis control individuals by sex, age, CKD duration, and index date.
- 2000-2013 data were obtained from the Taiwanese National Health Insurance Program.
- Median follow-up ranged from 22 (dialysis+NAF) to 53 (nondialysis, non-NAF) months.
- Funding: None.
- Crude mortality rates (per 1000 person-months; 95% CIs):
- Nondialysis, non-NAF (n=7034): 3.31 (3.14-3.49).
- Nondialysis+NAF (n=312): 10.98 (9.32-12.95).
- Dialysis, non-NAF (n=3426): 9.19 (8.73-9.66).
- Dialysis+NAF (n=247): 18.04 (15.38-21.16).
- Using nondialysis, non-NAF patients as a reference, mortality risk was higher (all P<.0001 with: style="list-style-type:circle;">
- Nondialysis+NAF: aHR, 1.968.
- Dialysis, non-NAF: aHR, 2.709.
- Dialysis+NAF: aHR, 3.466.
- Specific cause of death was not captured.
- Retrospective, observational design.