- Development of heart failure (HF) after a diagnosis of type 2 diabetes (T2D) poses the highest risk for mortality at 5 years, up to 5-fold greater than developing no cardiovascular disease (CVD).
Why this matters
- The authors say that they hope the findings will encourage clinicians to regularly evaluate their patients with T2D for HF.
- At each analysis year, ischemic heart disease (IHD) was the most commonly identified condition to develop, whereas HF was least common.
- 5-year risk of death at 5 years post-T2D diagnosis was highest with HF: 47.6% (95% CI, 44.8%-50.3%).
- For IHD, stroke, chronic kidney disease (CKD), and peripheral artery disease (PAD), this risk was
- Risk ratios (95% CIs) for mortality at 5 years with:
- HF: 3.0 (2.9-3.1).
- IHD: 1.3 (1.3-1.4).
- Stroke: 2.2 (2.1-2.2).
- CKD: 1.7 (1.7-1.8).
- PAD: 2.3 (2.3-2.4).
- HF added to any of these diagnoses compounded mortality risk.
- Analysis by age, sex, comorbidities, etc., did not change this pattern.
- Data for 2 Danish registry cohorts (1998-2008 and 2009-2015), all patients with a new T2D diagnosis.
- n=153,405; median follow-up of 9.7 (interquartile range, 5.8-13.9) years.
- Annual landmark timepoints postdiagnosis were used to estimate 5-year outcomes.
- Funding: Danish Heart Association; Boehringer Ingelheim.
- Severity of HF, T2D not known.