Takeaway
- In patients without known diabetes mellitus (KDM), pre-diabetes mellitus (pDM) is an independent predictor of major adverse cardiovascular events (MACEs) after myocardial infarction (MI).
- The 2-hour post-load plasma glucose (2h-PG) is a better predictor of post-MI MACE-free survival than the fasting plasma glucose (FPG) in these patients.
Why this matters
- At present, there is no clarity regarding the effect of pDM on post-MI prognosis.
Study design
- A retrospective cohort study of 850 MI survivors (whole cohort) and 348 matched pairs of patients with and without pDM (control group).
- The FPG and 2h-PG were measured using the glucose oxidase method.
- The first occurrence of MACEs (all-cause death, non-fatal reinfarction and ischaemic stroke) was obtained during the follow-up period.
- Funding: None.
Key results
- During a median follow-up of 2.8 years, MACEs reported in 25.1% and 16.4% patients with and without pDM (HR with pDM, 1.56; P=.003) in the whole cohort and in 24.1% and 17.2% patients with and without pDM (HR with pDM, 1.43; P=.033) in the control group, respectively.
- pDM was an independent predictor of MACE-free survival in the whole cohort (HR, 1.39; P=.033) and the control group (HR, 1.42; P=.043).
- The 2h-PG but not FPG was an independent predictor of MACE-free survival in the whole cohort (HR, 1.16) and control group (HR, 1.20; P<.0001 for both).
Limitations
- Retrospective design.
References
References
