The National Institute for Health and Care Excellence (NICE) has published updated recommendations on the management of neuropathic pain. Key recommendations are summarised below:
Principles of care
- When agreeing a treatment plan with the person discuss:
- severity of pain;
- its effect on lifestyle, daily activities, sleep and participation;
- underlying cause;
- benefits and possible adverse effects of pharmacological treatments;
- the importance of dosage titration and the titration process;
- coping strategies for pain and possible adverse effects; and
- non-pharmacological treatment options.
- Consider referring the person to a specialist pain service and/or a condition-specific service at any stage, if:
- they have severe pain;
- their pain significantly limits their lifestyle, daily activities, sleep and participation; or
- their underlying health condition has deteriorated.
- Continue existing treatments for people whose neuropathic pain is already effectively managed, with regular reviews.
- When introducing a new treatment, take into account overlap with the old treatments.
- After starting or changing a treatment, carry out an early review of dosage titration, tolerability and adverse effects.
- Carry out regular reviews of:
- pain control;
- effect on lifestyle, daily activities, sleep and participation;
- physical and psychological well-being;
- adverse effects; and
- continued need for treatment.
- When withdrawing or switching treatment, taper the withdrawal regimen.
Treatment
All neuropathic pain (except trigeminal neuralgia):
- Offer a choice of amitriptyline, duloxetine, gabapentin or pregabalin as initial treatment.
- If the initial treatment is not effective or is not tolerated, offer one of the remaining three drugs.
- Consider tramadol only if acute rescue therapy is needed.
- Consider capsaicin cream for people with localised neuropathic pain who wish to avoid, or who cannot tolerate, oral treatments.
- Do not start the following in non-specialist settings, unless advised by a specialist to do so:
- cannabis sativa extract,
- capsaicin patch,
- lacosamide,
- lamotrigine,
- levetiracetam,
- morphine,
- oxcarbazepine,
- topiramate,
- long-term tramadol,
- venlafaxine, and
- sodium valproate.
Trigeminal neuralgia:
- Offer carbamazepine as initial treatment.
- If carbamazepine is not effective, not tolerated or contraindicated, consider seeking expert advice from a specialist.
The guidance also includes recommendations on future research.
This article originally appeared on Univadis, part of the Medscape Professional Network.