- 4 weeks of nocturnal continuous positive airway pressure (CPAP) does little to suppress airway reactivity or inflammation in children with moderate-severe asthma in this small clinical trial .
Why this matters
- These authors had previously found an effect of 1 week of CPAP on airway reactivity in adults with mild asthma that was well-controlled.
- These children also were using inhaled corticosteroids or systemic corticosteroids.
- Although some improvement was seen, decreases in lower airway activity (PC20) were not significant within or between groups.
- Adherence was about 70% in both groups.
- The groups (sham vs real CPAP) also did not differ in asthma exacerbations requiring oral corticosteroid treatment.
- The groups did not differ in sputum eosinophil counts or cytokine values.
- Included children ages 8-17 years, moderate-severe asthma: 27 CPAP, 28 sham, for 4 weeks.
- Airway reactivity assessed via methacholine bronchial challenge.
- Funding: NIH.
- Small numbers, included only children with moderate-severe asthma, single-center.