Non-HDL-C levels more relevant than LDL-C in stable coronary artery disease | J Clin Lipidol.

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  • Non–HDL-C, in comparison to LDL-C, appears to be more relevant to atherogenic lipoprotein subfractions in patients with stable coronary artery disease, thus supporting the idea that it may be better in assessing cardiovascular risk.

Study Design

  • Cross-sectional study in 351 consecutive patients with stable coronary artery disease patients without lipid-lowering therapy.
  • The LDL and HDL separations were performed using the Lipoprint System.

Key Results

  • The cholesterol concentrations of LDL (large, medium, and small) and HDL (small) particles were increased (all P < .001) by non-HDL-C or LDL-C quartiles.
  • The mean LDL particle size and cholesterol concentrations of HDL (large) were decreased (both P < .001) by non-HDL-C quartiles.
  • The cholesterol in large HDL was negatively correlated with non-HDL-C (r = -0223, P < .001) but not with LDL-C.
  • The mean LDL particle size was more closely associated with non-HDL-C than LDL-C (r = -0.336 vs r = -0.136, both P < .05).
Why This Matters

  • LDL and HDL subfractions provide additional information regarding lipoprotein atherogenicity, and non–HDL-C was more relevant to cholesterol carried by small LDL particles.