- Non–HDL-C, in comparison to LDL-C, appears to be more relevant to atherogenic lipoprotein subfractions in patients with stable coronary artery disease, thus supporting the idea that it may be better in assessing cardiovascular risk.
- Cross-sectional study in 351 consecutive patients with stable coronary artery disease patients without lipid-lowering therapy.
- The LDL and HDL separations were performed using the Lipoprint System.
- The cholesterol concentrations of LDL (large, medium, and small) and HDL (small) particles were increased (all P < .001) by non-HDL-C or LDL-C quartiles.
- The mean LDL particle size and cholesterol concentrations of HDL (large) were decreased (both P < .001) by non-HDL-C quartiles.
- The cholesterol in large HDL was negatively correlated with non-HDL-C (r = -0223, P < .001) but not with LDL-C.
- The mean LDL particle size was more closely associated with non-HDL-C than LDL-C (r = -0.336 vs r = -0.136, both P < .05).
- LDL and HDL subfractions provide additional information regarding lipoprotein atherogenicity, and non–HDL-C was more relevant to cholesterol carried by small LDL particles.