- This meta-analysis suggests that non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk for gastroesophageal reflux disease (GERD).
- However, large cohort studies are needed to determine the causal relationship between NAFLD and the risk for GERD.
Why this matters
- Increasing evidence suggests that NAFLD is associated with an increased risk for extra-hepatic conditions. However, the association of NAFLD with the risk for GERD is currently uncertain.
- 9 observational studies (7 cross-sectional studies and 2 cohort studies) involving 185,118 participants met eligibility criteria after a search on PubMed, Scopus, Embase, and Web of Science.
- Funding: Health Commission of Jilin Province, China.
- Overall, the risk for GERD was higher in patients with NAFLD (random effect OR, 1.28; 95% CI, 1.12-1.44; I2=82%).
- The significant association between NAFLD and GERD was consistent for studies with:
- adjusted OR/HR (n=6; OR=1.16; 95% CI, 1.03-1.30), and
- unadjusted OR/HR (n=3; OR=2.09; 95% CI, 1.62-2.56).
- Heterogeneity among included studies.
- Publication bias.