Nonalcoholic fatty liver disease tied to increased risk for gastroesophageal reflux disease

  • Xue J & al.
  • Eur J Clin Invest
  • 19 Aug 2019

  • curated by Sarfaroj Khan
  • UK Clinical Digest
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Takeaway

  • This meta-analysis suggests that non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk for gastroesophageal reflux disease (GERD).
  • However, large cohort studies are needed to determine the causal relationship between NAFLD and the risk for GERD.

Why this matters

  • Increasing evidence suggests that NAFLD is associated with an increased risk for extra-hepatic conditions. However, the association of NAFLD with the risk for GERD is currently uncertain.

Study design

  • 9 observational studies (7 cross-sectional studies and 2 cohort studies) involving 185,118 participants met eligibility criteria after a search on PubMed, Scopus, Embase, and Web of Science.
  • Funding: Health Commission of Jilin Province, China.

Key results

  • Overall, the risk for GERD was higher in patients with NAFLD (random effect OR, 1.28; 95% CI, 1.12-1.44; I2=82%).
  • The significant association between NAFLD and GERD was consistent for studies with:
    • adjusted OR/HR (n=6; OR=1.16; 95% CI, 1.03-1.30), and
    • unadjusted OR/HR (n=3; OR=2.09; 95% CI, 1.62-2.56).

Limitations

  • Heterogeneity among included studies.
  • Publication bias.