- Dissolving triamcinolone-embedded microneedles are associated with significant keloid volume reductions, according to results from a small clinical trial.
Why this matters
- Corticosteroid injections, the standard first-line treatment, are associated with significant pain.
- Microneedle treatment was associated with reduced keloid volume after 4 weeks (mean change, −9.1 mm3; P=.001); control keloids increased in size during this period (mean change, +7.2 mm3; P=.104; P=.019 for treated vs control keloids; phase 1).
- In a second treatment and analysis conducted 6 months later with a 4 times higher dose of triamcinolone (phase 2), microneedle treatment was again associated with reduced keloid volume after 4 weeks (mean change, −22.1 mm3; P=.001); control keloids increased in size during this time (mean change, +6.7 mm3; P=.545; P=.035 for treated vs control keloids).
- The treatment-associated reduction in keloid volume in phase 2 was significantly higher than in phase 1 (P=.029).
- 27 patients with keloids were included; 2 similar keloids on each patient either received microneedle treatment or served as a control.
- Funding: National Medical Research Council, Singapore.
- Small patient sample size.
- Treatment was based on easy-to-reach keloid location and not randomized.
- Significant differences in baseline volumes of control vs treated keloids.