- Nodal grouping (NG), the presence of ≥3 contiguous lymph nodes (LNs) within 1 LN region, is associated with the survival outcomes of patients with nasopharyngeal carcinoma (NPC).
Why this matters
- Prognostic factors are useful for guiding patient management.
- NG was associated with OS (HR, 1.64; P=.011), PFS (HR, 1.62; P=.002), distant metastasis-free survival (DMFS; HR, 1.97; P=.001), and regional recurrence-free survival (HR, 1.62; P=.037) in multivariate analysis.
- Upgrading patients with NG from stage N1 to stage N2 improved the C-index of the American Joint Committee on Cancer system for prediction of PFS (0.664 vs 0.658; P=.022) and DMFS (0.699 vs 0.690; P=.005).
- In patients with NG and stage N1/2 disease, induction chemotherapy was associated with improved OS (P=.022), PFS (P=.007), and DMFS (P=.021).
- 1224 patients with NPC were analyzed for the prognostic value of NG.
- Funding: National Natural Science Foundation of China; Science and Technology Planning Project of Guangzhou City; Science and Technology Development Special Funds of Guangdong Province; Health & Medical Collaborative Innovation Project of Guangzhou City.
- No histological confirmation of metastatic LNs.
- Retrospective study.