NPC: PICC-associated VTE tied to poorer survival in Chinese study

  • Liang YJ & al.
  • BMC Cancer
  • 29 Dec 2018

  • curated by Brian Richardson, PhD
  • Univadis Clinical Summaries
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Takeaway

  • A retrospective study suggests that symptomatic venous thromboembolism (VTE) associated with peripherally inserted central catheters (PICCs) is linked to decreased survival of patients with nonmetastatic nasopharyngeal carcinoma (NPC).

Why this matters

  • PICC-associated VTE is common in this patient population.

Key results

  • Overall incidence of VTE was 7.20%.
  • VTE was associated with reduced 5-year PFS (77.5% vs 87.6%; P<.001 distant metastasis-free survival vs and locoregional recurrence-free os in propensity score-matched analysis.>
  • VTE had a hazard ratio of 2.92 (95% CI, 2.06-4.15; P<.001 in multivariate analysis.>
  • In subgroup analysis, 5-year PFS was similar for patients with superficial VTE vs deep vein VTE (P=.645), and 3-year PFS was similar for patients treated with low-molecular-weight heparin, warfarin, rivaroxaban, or other treatments (P=.228).

Study design

  • 3012 patients with nonmetastatic NPC were included.
  • 213 patients with VTE and 852 without VTE were included in the propensity score matching adjusted for sex, age, radiotherapy technique, stage, and pretreatment Epstein-Barr Virus DNA.
  • Funding: None.

Limitations

  • Retrospective study design.