- A retrospective study suggests that symptomatic venous thromboembolism (VTE) associated with peripherally inserted central catheters (PICCs) is linked to decreased survival of patients with nonmetastatic nasopharyngeal carcinoma (NPC).
Why this matters
- PICC-associated VTE is common in this patient population.
- Overall incidence of VTE was 7.20%.
- VTE was associated with reduced 5-year PFS (77.5% vs 87.6%; P<.001 distant metastasis-free survival vs and locoregional recurrence-free os in propensity score-matched analysis.>
- VTE had a hazard ratio of 2.92 (95% CI, 2.06-4.15; P<.001 in multivariate analysis.>
- In subgroup analysis, 5-year PFS was similar for patients with superficial VTE vs deep vein VTE (P=.645), and 3-year PFS was similar for patients treated with low-molecular-weight heparin, warfarin, rivaroxaban, or other treatments (P=.228).
- 3012 patients with nonmetastatic NPC were included.
- 213 patients with VTE and 852 without VTE were included in the propensity score matching adjusted for sex, age, radiotherapy technique, stage, and pretreatment Epstein-Barr Virus DNA.
- Funding: None.
- Retrospective study design.