- Idiopathic pulmonary fibrosis (IPF) is associated with significantly worse survival and increased recurrence risk in patients with surgically resected stage I-III NSCLC.
Why this matters
- IPF is a known risk factor for primary lung cancer, but its influence on recurrence risk after surgery was unknown.
- 3416 patients underwent surgical resection for stage I-III NSCLC.
- Funding: None.
- 96 patients had underlying IPF.
- Compared with patients without IPF, those with IPF were more likely to be male, older, have squamous cell carcinoma, and have stage II or III disease (P<.001 for all>
- Recurrence was significantly more likely in those with IPF (44.8% vs 25.5%; P=0.002).
- At 5 years, IPF group had a significantly worse recurrence-free survival rate (49.2% vs 69.1%; P<.001 os vs p and cancer-specific survival months>
- After multivariable analysis, IPF was associated with recurrence risk (adjusted HR, 2.68; P=.001) and worse OS (adjusted HR, 1.98; P=.018).
- Retrospective study.
- Regional (South Korea).