NSCLC: idiopathic pulmonary fibrosis linked to worse outcomes after surgery

  • Song MJ & al.
  • PLoS One
  • 1 Jan 2020

  • curated by Kelli Whitlock Burton
  • Univadis Clinical Summaries
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Takeaway

  • Idiopathic pulmonary fibrosis (IPF) is associated with significantly worse survival and increased recurrence risk in patients with surgically resected stage I-III NSCLC.

Why this matters

  • IPF is a known risk factor for primary lung cancer, but its influence on recurrence risk after surgery was unknown.

Study design

  • 3416 patients underwent surgical resection for stage I-III NSCLC.
  • Funding: None.

Key results

  • 96 patients had underlying IPF.
  • Compared with patients without IPF, those with IPF were more likely to be male, older, have squamous cell carcinoma, and have stage II or III disease (P<.001 for all>
  • Recurrence was significantly more likely in those with IPF (44.8% vs 25.5%; P=0.002).
  • At 5 years, IPF group had a significantly worse recurrence-free survival rate (49.2% vs 69.1%; P<.001 os vs p and cancer-specific survival months>
  • After multivariable analysis, IPF was associated with recurrence risk (adjusted HR, 2.68; P=.001) and worse OS (adjusted HR, 1.98; P=.018).

Limitations

  • Retrospective study.
  • Regional (South Korea).