- A prior cancer history has an effect on survival in patients with newly diagnosed NSCLC, but the effect varies on the basis of the stage of NSCLC.
Why this matters
- Clinical NSCLC trials often exclude patients with a prior cancer history, contributing to the lack of data on the effect previous malignancies have on outcomes for newly diagnosed patients with NSCLC.
- 821,323 adult patients aged 20-89 years from the National Cancer Database, diagnosed with stage I-IV invasive NSCLC between 2004 and 2014.
- Funding: None disclosed.
- Overall, 21.9% had prior cancer history; prevalence increased during the study period from 19.1% to 23.5%.
- Patients with NSCLC with a prior cancer history had slightly better unadjusted 5-year OS (9.8% vs 9.5%; P<.0001>
- Prior cancer history is associated with worse OS among patients with NSCLC with stage I (42.22 vs 53.95 months; P<.0001 and stage ii vs months p but not those with iii or iv disease.>
- Overall, prior cancer history associated with worse OS in 51.4%, better OS in 32.3%, and no significant association in 16.3%.
- No data on prior cancer tumor type, stage, or treatment.
- Retrospective study.