NSCLC: prior malignancy has variable effect on survival

  • Lung Cancer

  • curated by Kelli Whitlock Burton
  • Univadis Clinical Summaries
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Takeaway

  • A prior cancer history has an effect on survival in patients with newly diagnosed NSCLC, but the effect varies on the basis of the stage of NSCLC.

Why this matters

  • Clinical NSCLC trials often exclude patients with a prior cancer history, contributing to the lack of data on the effect previous malignancies have on outcomes for newly diagnosed patients with NSCLC.

Study design

  • 821,323 adult patients aged 20-89 years from the National Cancer Database, diagnosed with stage I-IV invasive NSCLC between 2004 and 2014.
  • Funding: None disclosed.

Key results

  • Overall, 21.9% had prior cancer history; prevalence increased during the study period from 19.1% to 23.5%.
  • Patients with NSCLC with a prior cancer history had slightly better unadjusted 5-year OS (9.8% vs 9.5%; P<.0001>
  • Prior cancer history is associated with worse OS among patients with NSCLC with stage I (42.22 vs 53.95 months; P<.0001 and stage ii vs months p but not those with iii or iv disease.>
  • Overall, prior cancer history associated with worse OS in 51.4%, better OS in 32.3%, and no significant association in 16.3%. 

Limitations

  • No data on prior cancer tumor type, stage, or treatment.
  • Retrospective study.

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