NSCLC resection: recurrence risk no higher with prior cancer history

  • Nakao K & al.
  • Ann Thorac Surg
  • 14 Aug 2019

  • curated by Kelli Whitlock Burton
  • Univadis Clinical Summaries
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Takeaway

  • Having a history of extrathoracic malignancy did not increase the risk for recurrence after surgical resection of NSCLC.

Why this matters

  • There are few data on outcomes in this patient population, and no consensus among clinicians about when these resections are appropriate.

Study design

  • 878 patients underwent curative lung resection for stage I-III NSCLC.
  • Median follow-up after resection, 7.55 years.
  • Funding: None disclosed.

Key results

  • 22.3% had a prior treatment history for extrathoracic malignancy.
  • Stage I NSCLC was more common in patients with a prior malignancy (96.4% vs 74.2%; P<.001>
  • Patients with prior malignancy had better 5-year recurrence-free survival (RFS) than those without in all patient groups (79.8% vs 69.6%; P=.008).
  • Patients with stage I NSCLC and previous malignancies had worse 5-year OS (88.5% vs 79.9%; P<.001>
  • After multivariable analysis, previous extrathoracic malignancies were associated with worse prognosis (aHR, 2.09; P<.001 but not rfs.>

Limitations

  • Retrospective, single-center study.