- Having a history of extrathoracic malignancy did not increase the risk for recurrence after surgical resection of NSCLC.
Why this matters
- There are few data on outcomes in this patient population, and no consensus among clinicians about when these resections are appropriate.
- 878 patients underwent curative lung resection for stage I-III NSCLC.
- Median follow-up after resection, 7.55 years.
- Funding: None disclosed.
- 22.3% had a prior treatment history for extrathoracic malignancy.
- Stage I NSCLC was more common in patients with a prior malignancy (96.4% vs 74.2%; P<.001>
- Patients with prior malignancy had better 5-year recurrence-free survival (RFS) than those without in all patient groups (79.8% vs 69.6%; P=.008).
- Patients with stage I NSCLC and previous malignancies had worse 5-year OS (88.5% vs 79.9%; P<.001>
- After multivariable analysis, previous extrathoracic malignancies were associated with worse prognosis (aHR, 2.09; P<.001 but not rfs.>
- Retrospective, single-center study.