- Sarcopenia is significantly associated with worse OS and PFS, but not with increased risk for postoperative complications in patients with NSCLC who underwent surgical resection with curative intent.
Why this matters
- Patients with NSCLC undergoing curative surgery should receive a preoperative CT to determine the presence of sarcopenia.
- 391 people with NSCLC underwent curative surgical resection.
- Median follow-up, 55.3 months.
- Funding: None disclosed.
- 50.6% had preoperatively diagnosed sarcopenia.
- 19.4% underwent sublobar resection, 79.8% lobectomy, and 0.8% pneumonectomy.
- Patients with sarcopenia had worse outcomes than those without:
- 5-year OS: 59.0% vs 87.5% (P<.001>
- 5-year RFS: 47.8% vs 75.6% (P<.001>
- Cancer-specific mortality: 18.7% vs 9.3% (P=.009).
- Respiratory-related mortality: 16.6% vs 1.6% (P<.001>
- Worse OS: aHR, 3.33 (P<.001>
- Worse RFS: aHR, 2.76; P<.001>
- But not with increased risk for postoperative complications.
- Single-center retrospective study.