- Sarcopenia is an independent predictor of poor 5-year OS after the surgical resection of NSCLC.
Why this matters
- Studies of the role of sarcopenia in predicting the prognosis of patients with NSCLC have yielded conflicting results.
- Meta-analysis of 6 cohort studies with 1213 patients with NSCLC with (n=422) or without (n=791) sarcopenia.
- Funding: None disclosed.
- Patients with NSCLC with sarcopenia had a significantly lower 5-year OS than those without after surgical resection (61.1% vs 74.2%; random effects: risk ratio [RR], 1.63; 95% CI, 1.13-2.33).
- No significant difference between groups in 5-year DFS (random effects: RR, 1.14; 95% CI, 0.59-2.17), but that analysis included only 3 studies with 557 patients.
- Sarcopenia was an independent predictor of poor OS in patients with NSCLC after surgical resection (random effects: HR, 2.85; 95% CI, 1.67-4.86).
- On analysis by disease stage, sarcopenia was a significant predictor of poor OS in patients with stage I NSCLC (HR, 4.68; 95% CI, 2.76-7.94) and in patients with all stages of NSCLC (HR, 1.71; 95% CI, 1.21-2.41).
- Heterogeneity among included studies.