NSCLC: SBRT, sublobar resection offer similar outcomes

  • Lung Cancer

  • curated by Kelli Whitlock Burton
  • Univadis Clinical Summaries
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Takeaway

  • Stereotactic body radiation therapy (SBRT) and sublobar resection offer similar outcomes for patients with early-stage NSCLC.

Why this matters

  • Studies comparing SBRT and sublobar resection in patients with NSCLC are lacking.

Study design

  • 221 patients with stage I NSCLC underwent sublobar resection (n=151) or SBRT (n=70).
  • Funding: None.

Key results

  • 95% of surgical patients underwent video-assisted thorascopic surgery.
  • Median length of hospital stay for surgical patients was 4 days, 23% had complications, and 13% were readmitted within 30 days.
  • 89% of SBRT patients were considered medically inoperable.
  • 17% of SBRT patients had adverse effects.
  • 90% (95% CI, 82%-94%) of the surgical group and 85% (95% CI, 65%-94%) of the SBRT group were free from local recurrence at 3 years (P=.71).
  • Disease-free survival at 3 years was 42% (95% CI, 34%-50%) for surgery vs 29% (95% CI, 18%-41%) for SBRT, but there was no difference between groups for cancer-specific DFS (P=.84).
  • After multivariable analysis, no difference in OS was seen between groups (HR, 1.20; 95% CI, 0.74-1.95).

Limitations

  • Retrospective, single-center study.

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