- High BMI and diabetes during pregnancy are linked to increased rates of pediatric neurodevelopmental and neuropsychiatric diagnoses.
Why this matters
- Diabetes and obesity may affect neurodevelopment.
- Higher maternal BMI with no diabetes was tied to increased risk (HRs) for neurodevelopmental and neuropsychiatric ICD codes in the children:
- BMI ≥30 to 2: 1.30 (95% CI, 1.24-1.36).
- BMI ≥35 kg/m2: 1.43 (95% CI, 1.33-1.54).
- Diabetes plus obesity added to the association (HRs) vs obesity only:
- Type 2 diabetes + BMI ≥35 kg/m2: 1.97 (95% CI, 1.64-2.37);
- Gestational diabetes + BMI ≥35 kg/m2: 1.61 (95% CI, 1.50-1.72).
- The most common pediatric diagnoses were mood disorders, autism spectrum disorder, ADHD, and conduct disorders.
- Population-based cohort study.
- Cohort obtained from a nationwide registry in Finland, 2019.
- Exposures included maternal prepregnancy BMI, insulin-treated pregestational diabetes, pregestational type 2 diabetes, and gestational diabetes.
- Outcome measures included ICD neurodevelopmental and neuropsychiatric diagnoses and prescription of psychotropic drugs among 649,043 children resulting from these pregnancies.
- Funding: THL National Institute for Health and Welfare, Drug and Pregnancy Project; Swedish Research Council; and China Scholarship Council.
- Information on blood glucose levels and preeclampsia not available.
- Results show correlation, not causation.