Obstructive sleep apnoea linked to oesophageal cancer risk

  • Hadi YB & al.
  • J Gastroenterol Hepatol
  • 10 Jul 2019

  • International Clinical Digest
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Takeaway

  • Patients with obstructive sleep apnoea (OSA) are more likely to develop Barrett's oesophagus (BO).

Why this matters

  • Severe OSA may indicate the need for endoscopic BO screening, in addition to risk factors specified in current guidelines (white, male, ≥50 years old, gastroesophageal reflux disease [GERD] symptoms for >10 years).

Study design

  • Researchers analysed the health records of patients who underwent both polysomnography and oesophagogastroduodenoscopy (n=1091; 60.9% female; mean age, 53.5±12.2 years).
  • Funding: None.

Key results

  • Patients with OSA had a greater risk for BO that was independent of other risk factors (OR, 3.24; 95% CI, 1.71-6.81; P<.001>
  • This risk increased with OSA severity, measured in 10-point apnoea-hypopnoea index increments (OR, 1.10; 95% CI, 1.02-1.19).

Limitations

  • The study was retrospective and single-centre.