Takeaway
- Supplementation of omega-3 polyunsaturated fatty acids (OPFAω-3) may increase prophylactic effects of amitriptyline in patients with migraine.
Why this matters
- For patients who are not getting full benefits from amitriptyline, supplementation with OPFAω-3 may help.
Key results
- Nine patients dropped out because of adverse effects from amitriptyline.
- Patients who took OPFAω-3 saw an 80.0% reduction in the number of headache days in 66.7% of patients, whereas 33.3% of placebo patients saw the same level reduction (P=.036).
Study design
- Randomized, double-blind, placebo-controlled trial of 60 patients treated with amitriptyline prophylaxis.
- Patients were split into 2 groups with the addition of OPFAω-3 or a placebo and followed for 60 d.
- Funding: No specific funding.
Limitations
- Small sample size, relatively short follow-up.
Only healthcare professionals with a Univadis account have access to this article.
You have reached your limit of complementary articles
Free Sign Up Available exclusively to healthcare professionalsLogin to
account
Don’t have an account? Get started