Omega-3 polyunsaturated fatty acids as a supplement to migraine prophylaxis

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  • Supplementation of omega-3 polyunsaturated fatty acids (OPFAω-3) may increase prophylactic effects of amitriptyline in patients with migraine.

Why this matters

  • For patients who are not getting full benefits from amitriptyline, supplementation with OPFAω-3 may help.

Key results

  • Nine patients dropped out because of adverse effects from amitriptyline.
  • Patients who took OPFAω-3 saw an 80.0% reduction in the number of headache days in 66.7% of patients, whereas 33.3% of placebo patients saw the same level reduction (P=.036).

Study design

  • Randomized, double-blind, placebo-controlled trial of 60 patients treated with amitriptyline prophylaxis.
  • Patients were split into 2 groups with the addition of OPFAω-3 or a placebo and followed for 60 d.
  • Funding: No specific funding.


  • Small sample size, relatively short follow-up.