- From 2007 to 2017, rates of drug-use-associated infective endocarditis (DUA-IE) and hospitalizations for surgery increased more than 12-fold in North Carolina (NC).
Why this matters
- Address underlying drug-use disorder (especially in younger patients) to mitigate risk for reinfection from injection drug use.
- 11% (2602/22,825) IE hospitalizations for DUA-IE.
- Annual DUA-IE hospitalizations rose from 64 (0.92/100,000) in 2007-2008 to 867 (10.95/100,000) in 2016-2017.
- Corresponding annual hospitalizations with valve surgery rose from 1.62/100,000 (2007-2008) to 3.26/100,000 (2016-2017); DUA-IE hospitalizations with surgery rose from
- In 2017, 42% of IE valve surgeries were performed in patients with DUA-IE.
- DUA-IE hospitalizations occurred more frequently in younger (median age, 35 [interquartile range (IQR), 28-45] years) vs older (median, 67 [IQR, 54-79] years) persons.
- DUA-IE hospitalizations with valve surgery occurred more often in younger (median, 33 [IQR, 27-42] years) vs older (median, 56 [IQR, 44-66] years) people.
- Opioids were the most commonly reported drug (62% of cases, n=176); 18.24% cases (n=52/176) coded for HCV.
- Retrospective discharge data analysis of NC DUA-IE hospitalization rates and related valve surgery, patient characteristic from 2007 to 2017.
- Funding: NIH.
- Coding inaccuracies.
- Reliance on HCV infection as drug-use indicator.
- Underestimated IE prevalence.