- Chemoradiotherapy (CRT) is associated with improved survival of patients aged 70+ years with oropharyngeal squamous cell carcinoma (OPSCC), regardless of HPV status, according to a review of the National Cancer Database.
Why this matters
- The role of chemotherapy in elderly patients with OPSCC is not well understood.
- CRT was associated with improved OS compared with radiotherapy alone in multivariate analysis (HR, 0.74; P<.001 style="list-style-type:circle;">
- This result was confirmed in propensity score-matched analysis (P<.001>
- 1965 patients aged 70+ years with locally advanced (cT1-2N1-3, cT3-4N0-3) OPSCC, 58% with HPV-positive status and 42% with HPV-negative status, were analyzed for associations between treatment modality (61.6% received CRT, 38.4% received radiotherapy alone) and survival.
- Funding: None disclosed.
- Retrospective analysis of large database.