OS after lung cancer surgery similar with or without COPD

  • Lung Cancer

  • curated by Kelli Whitlock Burton
  • Univadis Clinical Summaries
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Takeaway

  • People with mild-to-moderate COPD who undergo surgical resection for early-stage NSCLC have similar 5-year OS to that of patients without COPD.

Why this matters

  • Patients with COPD were more likely to forgo surgery than those without COPD, even though the findings suggest outcomes are similar after surgery.

Study design

  • Meta-analysis of 10 studies of 6899 patients with operable NSCLC and analysis of 10,054 patients with lung cancer from a National Lung Screening Trial-American College of Radiology Imaging Network (NLST-ACRIN) cohort.
  • Funding: University of Auckland.

Key results

  • In the meta-analysis cohort, OS was not significantly different after surgery between patients with COPD and those without (OR, 0.91; 95% CI, 0.84-1.00).
  • 5-year OS was also not significantly different between COPD and no-COPD groups in the NLST-ACRIN cohort (84% vs 81%; P=.65).
  • Prevalence of COPD in patients who did not undergo surgery was 92%-100%, significantly higher than the expected 40%-50% rate in patients who underwent surgery.

Limitations

  • No randomized controlled trials in the analysis.