- Obstructive sleep apnea (OSA) is an independent predictor of dyslipidemia, including abnormal total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides (TG).
- Multiple measures of OSA, including apnea-hypopnea index (AHI) and oxygen-desaturation index (ODI), are predictive.
Why this matters
- Metabolic dysfunction is thought to mediate OSA’s relationship with cardiovascular complications, but details are not completely understood.
- TC ≥200 mg/dL:
- OR with rising ODI quartiles vs lowest quartile: 1.31, 1.30, 1.31 (all P<.001>
- OR in patients with highest ODI quartile: 1.48 (P=.008).
- OR with highest vs lowest AHI quartile: 1.40 (P=.024).
- With highest vs lowest ODI quartile: 1.41 (P=.021).
- OR with rising AHI quartiles vs lowest quartile: 1.26 (P=.003), 1.42 (P<.001 class="">
- Cross-sectional study of multinational cohort in European Sleep Apnea Database (ESADA) (n=8592).
- Participants lacked dyslipidemia diagnosis and were not using lipid-lowering drugs.
- Researchers adjusted for multiple covariates while comparing OSA measures with lipid profiles.
- Funding: European Union, European Respiratory Society, ResMed Foundation, Philips Respironics Foundation.
- Referral bias risk; results might not apply to community populations.
- Causal relationship not established.
- Unknown whether treating OSA would affect lipid status.