OSA predicts dyslipidemia

  • Gündüz C & al.
  • Respirology
  • 21 Aug 2018

  • curated by Jenny Blair, MD
  • Clinical Essentials
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Takeaway

  • Obstructive sleep apnea (OSA) is an independent predictor of dyslipidemia, including abnormal total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides (TG).
  • Multiple measures of OSA, including apnea-hypopnea index (AHI) and oxygen-desaturation index (ODI), are predictive.

Why this matters

  • Metabolic dysfunction is thought to mediate OSA’s relationship with cardiovascular complications, but details are not completely understood.

Key results

  • TC ≥200 mg/dL:
    • OR with rising ODI quartiles vs lowest quartile: 1.31, 1.30, 1.31 (all P<.001>
  • HDL
  • OR in patients with highest ODI quartile: 1.48 (P=.008).
  • LDL ≥100 mg/dL: 
    • OR with highest vs lowest AHI quartile: 1.40 (P=.024).
    • With highest vs lowest ODI quartile: 1.41 (P=.021).
  • TG ≥150 mg/dL:
    • OR with rising AHI quartiles vs lowest quartile: 1.26 (P=.003), 1.42 (P<.001 class=""> 
  • Study design

    • Cross-sectional study of multinational cohort in European Sleep Apnea Database (ESADA) (n=8592).
    • Participants lacked dyslipidemia diagnosis and were not using lipid-lowering drugs.
    • Researchers adjusted for multiple covariates while comparing OSA measures with lipid profiles.
    • Funding: European Union, European Respiratory Society, ResMed Foundation, Philips Respironics Foundation.

    Limitations

    • Referral bias risk; results might not apply to community populations.
    • Causal relationship not established.
    • Unknown whether treating OSA would affect lipid status.

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