- A model based on 4 histopathological factors is predictive of nodal metastasis in patients with oral squamous cell carcinoma (OSCC).
Why this matters
- Better understanding of predictive factors can assist with patient management.
- Tumor size was associated with metastasis (P<.01 or for t2 t3 and t4 relative to t1>
- Tumor site was associated with metastasis (P<.01 or for tongue vs buccal mucosa>
- Pattern of invasion (POI) was associated with metastasis (P<.01 or for pattern iii and iv relative to ii>
- Depth of invasion was associated with metastasis (P<.01>
- A model based on these 4 factors had an area under the curve of 0.77 for predicting metastasis.
- At a predicted probability of 0.25 for metastasis as a cutoff, sensitivity was ~83% and specificity was ~63%.
- Study of 623 patients with buccal mucosal OSCC or patients with tongue SCC with clinically negative neck were analyzed for factors associated with development of nodal metastasis.
- Funding: None disclosed.
- Retrospective study.