OSCC: 4-factor model predicts nodal metastasis

  • De Silva RK & al.
  • PLoS ONE
  • 1 Jan 2018

  • curated by Brian Richardson, PhD
  • Univadis Clinical Summaries
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Takeaway

  • A model based on 4 histopathological factors is predictive of nodal metastasis in patients with oral squamous cell carcinoma (OSCC).

Why this matters

  • Better understanding of predictive factors can assist with patient management.

Key results

  • Tumor size was associated with metastasis (P<.01 or for t2 t3 and t4 relative to t1>
  • Tumor site was associated with metastasis (P<.01 or for tongue vs buccal mucosa>
  • Pattern of invasion (POI) was associated with metastasis (P<.01 or for pattern iii and iv relative to ii>
  • Depth of invasion was associated with metastasis (P<.01>
  • A model based on these 4 factors had an area under the curve of 0.77 for predicting metastasis.
  • At a predicted probability of 0.25 for metastasis as a cutoff, sensitivity was ~83% and specificity was ~63%.

Study design

  • Study of 623 patients with buccal mucosal OSCC or patients with tongue SCC with clinically negative neck were analyzed for factors associated with development of nodal metastasis.
  • Funding: None disclosed.

Limitations

  • Retrospective study.

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